In this episode of Off Script we spoke with Dr. Luca Allievi, PhD, R&D Chemist and Project Manager at Valsynthese, about the role of flow chemistry in complex pharmaceutical manufacturing. The conversation explores how flow reactors work, where continuous processing offers advantages over batch production, and how the technology is being applied to azide chemistry, gas-liquid reactions, and highly reactive reagents.
Hazardous chemistry presents recurring challenges for contract development and manufacturing organizations (CDMOs) across the industry: highly exothermic reactions, toxic or carcinogenic and corrosive substances, unstable intermediates, high pressure/temperature processes, and stringent requirements for containment, exhaust gas purification, occupational safety, and change management.
This white paper describes these challenges using key reaction classes and demonstrates which technical and organizational measureshave proven effective in practice.
In this episode of the Pharma Matters Podcast, host Ben Locwin speaks with Dr. Achim Gsponer, Head of Production at Valsynthese, about the challenges and opportunities of working with isoprene—a highly volatile and reactive building block used in specialty chemicals.
Our full three-part blog series, “The Chemistry of Imides”, is now available as a single downloadable document — bringing together all three chapters in one place.
A complete view of imide chemistry, performance, and sustainability. Download it!
In this final chapter, we explore how polyimides can support sustainability goals without compromising performance — focusing on BPA‑free PEIs enabled by phenolic imide derivatives. Discover how molecular design can reduce toxicity, improve environmental profiles, and unlock new functional possibilities such as controlled cross‑linking, adhesion, and durability.
As global pharmaceutical supply chains face cost inflation,geopolitical instability, and new frameworks such as the EU’sCritical Medicines Act, the industry is redefining what resilience means. Today, we speak with Dr. Max Lauwiner about how quality, supply chain security, and agility can coexist-notas trade-offs, but as mutually reinforcing pillars of a modern pharma ecosystem.
In the first article of this series, we explored the foundations of imide chemistry, the unique stability of the imide ring, the influence of pendant groups, and the ways these structures support advanced materials.
In this second installment, we shift from fundamentals to functional innovation and examine how tailoringimide derivatives translates into measurable performance gains.
Imides are more than functional groups – they are platforms for property tuning in high-performance materials.
In this part 1 we explore structure, key properties and where imide chemistry enables performance in polymers, resins, electronics and advanced materials.
In this episode of Pharma Matters, Dr. Luca Allievi from Valsynthese SA shares how the application of Design of Experiments (DoE) can optimize a complex chemical process — improving yield, quality, and sustainability all at once.
Dr. Luca Mantilli, R&D chemist at Valsynthese, discusses how hydrogenation was implemented to bridge the gap between two of the company’s core hazardous chemistries: nitration and phosgenation.
